Virus genome reveals his animal origin

Reconstructed the origin of H1N1 through its genome analysis performed on 50 samples of virus collected in Mexico and in US: H1N1 is not similar to the other swine viruses but is composed of an assortment of gene segments of other flue viruses comes "by far". The news has been given in an anticipation of a Science magazine article to be published next week.

The genetic analysis of H1N1 was conducted by Rebecca Garten of the Centers for Disease Control and Prevention, and in collaboration with the World Health Organization WHO.

The analysis revealed that H1N1 does not like its closest relatives swine flue virus. This means that its genes have moved unnoticed for a very extended period of time suggesting that in future pig farms should be monitored to better monitor and predict the emergence of new flue viruses.

Experts have discovered that all eight gene segments that make up the genome of the virus H1N1 form together a combination of new genomic never reported so far no virus in pig and human flue: these eight segments instead have originated in an avian host and then have begun to circulate in pigs on several occasions between 1918 and 1998.

Six of the genetic segments have moved to North America starting in 1998 and are the result of an assembly of genes of human, porcine, avian flue. The other two segments are derived from Eurasian swine flue virus.

The fact that the genome of this new flue is so different from swine flue viruses of his relatives indicates that genes that ultimately led to the mosaic H1N1 were in circulation, completely unnoticed, for a long time.


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